Rather than clicking on the task bar and then safely removing the pendrive you can eaily do so creating a shortcut:

THE STEPS ARE

1)Create shortcut on your desktop by right click and selecting new shortcut from the menu.

2)Type "RunDll32.exe

Virtual memory using pendrive in xp/vista

> Insert Pen Drive (1GB atleast) in the USB port
(try to USE 4GB.)
> Let the PC detect it..

> After it finished his work, you HAVE TO DO THESE THINGS

How to Block USB Drives

a simple registry TRICK TO BLOCK USB drives (do it with care)

This explains how to disable ONLY USB storage devices(flash/Jump/external HD's) completely without disabling keyboards, mice, etc.

I decided to go this route after trying every other option I could find on the internet. So far this is the only way I have found to completely kill USB drives without ways to get around restrictions. edit: WITHOUT PURCHASING THIRD PARTY SOFTWARE ...